Welcome to the module. BS6006 provides an in-depth knowledge of genetic engineering and an introduction to bioinformatics. Main topics of study include:

Recombinant DNA technology: a comprehensive review of DNA cloning, gene libraries, PCR, recombinant gene expression, techniques used for analysis of human gene structure and function, including functional genomics.

The molecular analysis of disease: functional and positional cloning; types of genetic and physical maps used to locate disease genes; identification and molecular biology of disease genes eg cystic fibrosis and haemophilia; testing genes responsible for common genetic diseases.

Genome organisation, analysis: genomes of prokaryotes; genomes of eukaryotes; the human genome; genetic diversity; genome maps; genome sequencing; functional genomics; transcriptome, proteome. Advanced techniques in molecular biology.

Archives, information retrieval and alignments: nucleic acid sequence databases; genome databases; protein sequence databases; database searching; alignments and phylogenetic trees; dotplots and sequence alignments (PSI BLAST); archive gateways (ENTREZ, ExPASy, Ensembl)Genome expression: Microarray analysis, proteomics, eukaryotic genome expression.